Here is what I didto get the new FlexBuilder 2 - ColdFusion adapter.

My CF server is localhost:8500 so your config could be a little different.

After following the directions from macromdeia:
To install the FlexBuilder 2-ColdFusion Adapter:

1. Extract the files in the cfzorn.zip file as follows:
   

   File	Extract to:
   hf701-61119.jar	cfusion\lib\updates (mine was at C:\CFusionMX7\lib\updates)
   crossdomain.xml	your web root (for example wwwroot, or inetpub\wwwroot) (mine was at C:\CFusionMX7\wwwroot)
   flex-services.xml flex-services.xsd coldfusionsamples.xml	WEB-INF\flex (mine was at C:\CFusionMX7\wwwroot\WEB-INF) Note: The WEB-INF\flex directory does not already exist.

2. Modify the web.xml file, which is located in the WEB-INF directory by doing the following:.
   1. In the section of the file that contains the servlet configurations, add the following:
      <servlet> <servlet-name>MessageBrokerServlet</servlet-name> <servlet-class>coldfusion.bootstrap.BootstrapServlet</servlet-class> <init-param> <param-name>servlet.class</param-name> <param-value>flex.messaging.MessageBrokerServlet</param-value> <param-name>services.configuration.file</param-name> <param-value>/WEB-INF/flex/flex-services.xml</param-value> </init-param> <load-on-startup>14</load-on-startup> </servlet>
   2. In the section of the file that contains the servlet-mappings, add the following:
      <servlet-mapping id="macromedia_mapping_0"> <servlet-name>MessageBrokerServlet</servlet-name> <url-pattern>/flex2gateway/*</url-pattern> </servlet-mapping>
3. If your ColdFusion server uses something other than port 8500:
   1. Open the file C:\CFusionMX7\wwwroot\Web-INF\flex\flex-services.xml.
   2. Change the following to specify the port you are using:
      <endpoint uri="/flex2gateway/" port="8500" in flex-services.xml
   3. Save the file.
4. Restart the ColdFusion server.

I then did the following:
Created a com folder and then a local folder within com.
I then created a cfc named TestCFC.cfc with the following code:
<cfcomponent>
<cffunction name=”getTestString” returntype=”string”>
<cfreturn “Test from ColdFusion”>
</cffunction>
</cfcomponent>

I added the following to my coldfusionsamples.xml file:
<destination id=”TestCFC”>
<properties>
<source>com.local.TestCFC</source>
<lowercase-keys>true</lowercase-keys>
</properties>
<channels>
<channel ref=”my-cfamf”/>
</channels>
</destination>

I then created an mxml file with the following code:
<?xml version=”1.0″ encoding=”utf-8″?>
<mx:Application xmlns:mx=”http://www.macromedia.com/2005/mxml” xmlns=”*”>
<mx:RemoteObject id=”testCFC”
destination=”TestCFC”
result=”mx.controls.Alert.show(’result = ‘ + event.result, ‘Result’)”
fault=”mx.controls.Alert.show(’error = ‘ + event.fault, ‘Error’)”/>
<mx:Canvas width=”100%” height=”100%”>
<mx:Button click=”testCFC.getTestString()” label=”Get String” />
</mx:Canvas>
</mx:Application>

Lastly I added the following to my Project -> Properties -> Flex Compiler: